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最終更新日 2018/10/17 10:38:13
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最終更新日 2018/10/17 10:38:13
Shapeshifting RNAs guide innate immunity [Immunology]
from Journal of Biological Chemistry current issue (2018/10/12 16:06:18)
from Journal of Biological Chemistry current issue (2018/10/12 16:06:18)
The innate immune system can distinguish between RNAs of viral and cellular origin, but the basis for this discrimination is not known. A new paper by Calderon and Conn demonstrates that conformational plasticity determines the ability of one RNA sequence to bind to and activate the pattern recognition receptor OAS1/RNase L. In identifying a novel mode through which the immune response is naturally controlled, this finding opens new avenues toward developing approaches for the management of a wide range of viral infections.
A human cellular noncoding RNA activates the antiviral protein 2'-5'-oligoadenylate synthetase 1 [Gene Regulation]
from Journal of Biological Chemistry current issue (2018/10/12 16:06:18)
from Journal of Biological Chemistry current issue (2018/10/12 16:06:18)
The 2??5?-oligoadenylate synthetase (OAS) family of enzymes sense cytosolic dsRNA, a potent signal of viral infection. In response to dsRNA binding, OAS proteins synthesize the second messenger 2??5?- ...
Structure-function analyses of the ion channel TRPC3 reveal that its cytoplasmic domain allosterically modulates channel gating [Molecular Biophysics]
from Journal of Biological Chemistry current issue (2018/10/12 16:06:18)
from Journal of Biological Chemistry current issue (2018/10/12 16:06:18)
The transient receptor potential ion channels support Ca2+ permeation in many organs, including the heart, brain, and kidney. Genetic mutations in transient receptor potential cation channel subfamily ...
Reply to Meriney and Lacomis: Comment on direct aminopyridine effects on voltage-gated Ca2+ channels [Letters to the Editor]
from Journal of Biological Chemistry current issue (2018/10/12 16:06:18)
from Journal of Biological Chemistry current issue (2018/10/12 16:06:18)
Meriney and Lacomis (1) contended that the therapeutic actions of aminopyridines are mediated by voltage-gated K+ channels (Kv), but not voltage-gated Ca2+ channels (Cav). We originally showed that am ...
Reported direct aminopyridine effects on voltage-gated calcium channels is a high-dose pharmacological off-target effect of no clinical relevance [Letters to the Editor]
from Journal of Biological Chemistry current issue (2018/10/12 16:06:18)
from Journal of Biological Chemistry current issue (2018/10/12 16:06:18)
Wu et al. (1) present high-quality data, but we challenge their interpretation that they relate to the therapeutic use of aminopyridines (4-aminopyridine (4-AP) and 3,4-diaminopyridine (DAP)). They ar ...
Identification and characterization of ubiquitinylation sites in TAR DNA-binding protein of 43 kDa (TDP-43) [Cell Biology]
from Journal of Biological Chemistry current issue (2018/10/12 16:06:18)
from Journal of Biological Chemistry current issue (2018/10/12 16:06:18)
TAR DNA-binding protein of 43 kDa (TDP-43) forms pathological aggregates in neurodegenerative diseases, particularly in certain forms of frontotemporal dementia and amyotrophic lateral sclerosis. Path ...
Overexpression of quality control proteins reduces prion conversion in prion-infected cells [Molecular Bases of Disease]
from Journal of Biological Chemistry current issue (2018/10/12 16:06:18)
from Journal of Biological Chemistry current issue (2018/10/12 16:06:18)
Prion diseases are fatal infectious neurodegenerative disorders in humans and other animals and are caused by misfolding of the cellular prion protein (PrPC) into the pathological isoform PrPSc. These ...
Human interferon-ε and interferon-{kappa} exhibit low potency and low affinity for cell-surface IFNAR and the poxvirus antagonist B18R [Signal Transduction]
from Journal of Biological Chemistry current issue (2018/10/12 16:06:18)
from Journal of Biological Chemistry current issue (2018/10/12 16:06:18)
IFN? and IFN? are interferons that induce microbial immunity at mucosal surfaces and in the skin. They are members of the type-I interferon (IFN) family, which consists of 16 different IFNs, that all ...
Respiratory chain Complex I of unparalleled divergence in diplonemids [Genomics and Proteomics]
from Journal of Biological Chemistry current issue (2018/10/12 16:06:18)
from Journal of Biological Chemistry current issue (2018/10/12 16:06:18)
Mitochondrial genes of Euglenozoa (Kinetoplastida, Diplonemea, and Euglenida) are notorious for being barely recognizable, raising the question of whether such divergent genes actually code for functi ...
Subplasmalemmal hydrogen peroxide triggers calcium influx in gonadotropes [Cell Biology]
from Journal of Biological Chemistry current issue (2018/10/12 16:06:18)
from Journal of Biological Chemistry current issue (2018/10/12 16:06:18)
Gonadotropin-releasing hormone (GnRH) stimulation of its eponymous receptor on the surface of endocrine anterior pituitary gonadotrope cells (gonadotropes) initiates multiple signaling cascades that c ...
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