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最終更新日 2020/4/5 3:39:59
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最終更新日 2020/4/5 3:39:59
Correction: Mitosis-related phosphorylation of the eukaryotic translation suppressor 4E-BP1 and its interaction with eukaryotic translation initiation factor 4E (eIF4E). [Additions and Corrections]
from Journal of Biological Chemistry current issue (2020/4/3 16:05:56)
from Journal of Biological Chemistry current issue (2020/4/3 16:05:56)
VOLUME 294 (2019) PAGES 11840?11852In this study on mitotic mRNA translation, the authors report on cloned HeLa cell lines that were generated by CRISPR/Cas9 EIF4EBP1 knockout and then stable substitutions with either the EIF4EBP1 WT or codon S83A mutations. During cell line verification surveillance performed after publication, the authors found that 293T cells had been used instead of HeLa cells and were mislabeled (both HeLa and 293T cell lines had been initially targeted for EIF4EBP1 knockout). None of the conclusions are changed by this error. The authors regret the confusion generated by mis-stating the cell line used in this study and affirm the importance of routine cell line verification.
The microtubule-associated histone methyltransferase SET8, facilitated by transcription factor LSF, methylates {alpha}-tubulin [Developmental Biology]
from Journal of Biological Chemistry current issue (2020/4/3 16:05:56)
from Journal of Biological Chemistry current issue (2020/4/3 16:05:56)
Microtubules are cytoskeletal structures critical for mitosis, cell motility, and protein and organelle transport and are a validated target for anticancer drugs. However, how tubulins are regulated a ...
Bile acid sequestration reverses liver inȷury and prevents progression of nonalcoholic steatohepatitis in Western diet-fed mice [Metabolism]
from Journal of Biological Chemistry current issue (2020/4/3 16:05:56)
from Journal of Biological Chemistry current issue (2020/4/3 16:05:56)
Nonalcoholic fatty liver disease is a rapidly rising problem in the 21st century and is a leading cause of chronic liver disease that can lead to end-stage liver diseases, including cirrhosis and hepa ...
Mechanical stretch increases Kv1.5 current through an interaction between the S1-S2 linker and N-terminus of the channel [Membrane Biology]
from Journal of Biological Chemistry current issue (2020/4/3 16:05:56)
from Journal of Biological Chemistry current issue (2020/4/3 16:05:56)
The voltage-gated potassium channel Kv1.5 plays important roles in atrial repolarization and regulation of vascular tone. In the present study, we investigated the effects of mechanical stretch on Kv1 ...
Structural analyses of the Group A flavin-dependent monooxygenase PieE reveal a sliding FAD cofactor conformation bridging OUT and IN conformations [Enzymology]
from Journal of Biological Chemistry current issue (2020/4/3 16:05:56)
from Journal of Biological Chemistry current issue (2020/4/3 16:05:56)
Group A flavin-dependent monooxygenases catalyze the cleavage of the oxygen?oxygen bond of dioxygen, followed by the incorporation of one oxygen atom into the substrate molecule with the aid of NADPH ...
The E3 ubiquitin ligase STUB1 attenuates cell senescence by promoting the ubiquitination and degradation of the core circadian regulator BMAL1 [Cell Biology]
from Journal of Biological Chemistry current issue (2020/4/3 16:05:56)
from Journal of Biological Chemistry current issue (2020/4/3 16:05:56)
Cell senescence is one of the most important processes determining cell fate and is involved in many pathophysiological conditions, including cancer, neurodegenerative diseases, and other aging-associ ...
Emerging roles for R-loop structures in the management of topological stress [Gene Regulation]
from Journal of Biological Chemistry current issue (2020/4/3 16:05:56)
from Journal of Biological Chemistry current issue (2020/4/3 16:05:56)
R-loop structures are a prevalent class of alternative non-B DNA structures that form during transcription upon invasion of the DNA template by the nascent RNA. R-loops form universally in the genomes ...
Wilms tumor 1 regulates lipid accumulation in human endometrial stromal cells during decidualization [Gene Regulation]
from Journal of Biological Chemistry current issue (2020/4/3 16:05:56)
from Journal of Biological Chemistry current issue (2020/4/3 16:05:56)
We previously reported that the transcription factor Wilms tumor 1 (WT1) regulates the expression of insulin-like growth factor-binding protein-1 (IGFBP-1) and prolactin (PRL) during decidualization o ...
Tristetraprolin regulates necroptosis during tonic Toll-like receptor 4 (TLR4) signaling in murine macrophages [Signal Transduction]
from Journal of Biological Chemistry current issue (2020/4/3 16:05:56)
from Journal of Biological Chemistry current issue (2020/4/3 16:05:56)
The necrosome is a protein complex required for signaling in cells that results in necroptosis, which is also dependent on tumor necrosis factor receptor (TNF-R) signaling. TNF? promotes necroptosis, ...
Norrin restores blood-retinal barrier properties after vascular endothelial growth factor-induced permeability [Signal Transduction]
from Journal of Biological Chemistry current issue (2020/4/3 16:05:56)
from Journal of Biological Chemistry current issue (2020/4/3 16:05:56)
Vascular endothelial growth factor (VEGF) contributes to blood-retinal barrier (BRB) dysfunction in several blinding eye diseases, including diabetic retinopathy. Signaling via the secreted protein no ...
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