リンク集 KURENAI: Kyoto University Research Information Repository

タイトル: A screening for DNA damage response molecules that affect HIV-1 infection著者: Yoshinaga, Noriyoshi; Shindo, Keisuke; Matsui, Yusuke; Takiuchi, Yoko; Fukuda, Hirofumi; Nagata, Kayoko; Shirakawa, Kotaro; Kobayashi, Masayuki; Takeda, Shunichi; Takaori-Kondo, Akifumi抄録: Host DNA damage response molecules affect retroviral infection, as DNA intermediates of the viruses play essential roles in the viral life cycles. Although several such molecules have been reported, interactions between HIV-1 and host DNA damage response molecules have not been fully elucidated. To screen DNA damage response molecules that might affect HIV-1 infection, a set of 32 DNA-repair-deficient DT40 isogenic mutant cells were tested for HIV-1 infectivity. Seven out of the 32 clones showed less than 50% infectivity compared to parental DT40 cells, implying that DNA repair molecules deficient in these cells might support HIV-1 infection. Of these, EXO1 −/−, TP53BP1 −/− and WRN −/− cel ...