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タイトル: Tissue Nonspecific Alkaline Phosphatase Is Activated via a Two-step Mechanism by Zinc Transport Complexes in the Early Secretory Pathway著者: Fukunaka, Ayako; Kurokawa, Yayoi; Teranishi, Fumie; Sekler, Israel; Oda, Kimimitsu; Leigh Ackland, M; Faundez, Victor; Hiromura, Makoto; Masuda, Seiji; Nagao, Masaya; Enomoto, Shuichi; Kambe, Taiho抄録: A number of enzymes become functional by binding to zinc during their journey through the early secretory pathway. The zinc transporters (ZnTs) located there play important roles in this step. We have previously shown that two zinc transport complexes, ZnT5/ZnT6 heterodimers and ZnT7 homo-oligomers, are required for the activation of alkaline phosphatases, by converting them from the apo- to the holo-form. Here, we investigated the molecular mechanisms of this activation. ZnT1 and ZnT4 expressed in chicken DT40 cells did not contribute to the activation of tissue nonspecific alkaline phosphatase (TNAP). The reduced activity of TN ...

国立国会図書館は、東日本大震災で被災した自治体のウェブサイトを収集・保存しています。また、海外の機関が行っている震災関連ウェブサイトの保存にも協力しています。

タイトル: 言語能力概念と多文化共生 --「福井市営住宅入居事務取扱要綱」をめぐる問題を手がかりに--著者: 塚原, 信行

2011年1月31日月曜日をもちまして、川俣町ウェブサイトは、こちらのURL【http://www.town.kawamata.fukushima.jp/】からご覧いただけなくなります。今後は【http://www.town.kawamata.lg.jp/】からご覧いただきますとともに、ブックマークの変更をお願いいたします。こ

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インターネット資料収集保存事業（著作別）が公開されました。国内の公的機関が発信するインターネット資料を、著作別に収集・提供しています。

2010年4月1日より、国立国会図書館法に基づくインターネット資料の制度収集が始まりました。

2010年4月1日より、国立国会図書館法に基づくインターネット資料の制度収集が始まります。（付・プレスリリース）

タイトル: 大学での外国語学習における遠隔通信技術活用のための授業デザインに関する考察著者: 塚原, 信行抄録: This paper describes the experience of Spanish classes at the Aichi Prefectura! University in cooperation with the University of Barcelona (Spain) and tries to point out some factors to develop course design to maximize the efficiency of the use of network technologies in the classroom. In recent years, the introduction of network technologies into the foreign language classroom has become easier and less expensive and has provided us with a new possibility to face a real problem occurring in the class. However, if the course design does not take its peculiarity into account, we cannot benefit from the introduced technologies. In response to that, we adopted PDSA cycle and made the entire course "session driven". One of the advantages of PDSA cycle is its potentiality to act as a trigger to foster independent learners. Even though so ...

タイトル: Demonstration and Characterization of the Heterodimerization of ZnT5 and ZnT6 in the Early Secretory Pathway著者: Fukunaka, Ayako; Suzuki, Tomoyuki; Kurokawa, Yayoi; Yamazaki, Tomohiro; Fujiwara, Naoko; Ishihara, Kaori; Migaki, Hitoshi; Okumura, Katsuzumi; Masuda, Seiji; Yamaguchi-Iwai, Yuko; Nagao, Masaya; Kambe, Taiho抄録: The majority of CDF/ZnT zinc transporters form homo-oligomers. However, ZnT5, ZnT6, and their orthologues form hetero-oligomers in the early secretory pathway where they load zinc onto zinc-requiring enzymes and maintain secretory pathway functions. The details of this hetero-oligomerization remain to be elucidated, and much more is known about homo-oligomerization that occurs in other CDF/ZnT family proteins. Here, we addressed this issue using co-immunoprecipitation experiments, mutagenesis, and chimera studies of hZnT5 and hZnT6 in chicken DT40 cells deficient in ZnT5, ZnT6, and ZnT7 proteins. We found that hZnT5 and hZnT6 combine to form heter ...