リンク集 RSS/ATOM 記事

タイトル: A protocol of trial of ivermectin in COVID-19 treatment critically changed after its completion著者: Harada, Kouji H; Phosri, Arthit

タイトル: Discontinuation of pembrolizumab for advanced urothelial carcinoma without disease progression: Nationwide cohort study著者: Ito, Katsuhiro; Kita, Yuki; Yokomizo, Akira; Miki, Jun; Yoshio, Yuko; Matsumoto, Hiroaki; Segawa, Takehiko; Karashima, Takashi; Nishiyama, Naotaka; Imai, Kazuto; Suekane, Shigetaka; Nagasawa, Seiji; Higashi, Shin; Nishiyama, Hiroyuki; Kitamura, Hiroshi; Kobayashi, Takashi抄録: Pembrolizumab, an anti-programmed death 1 monoclonal antibody, has revolutionized the treatment of metastatic urothelial carcinoma. However, the optimal treatment duration for treatment responders has not been established. To address this, we retrospectively assess the treatment outcomes and duration of pembrolizumab for patients whose best response was complete response (CR) or partial response (PR) in a Japanese nationwide cohort of platinum-refractory metastatic urothelial carcinoma. Of 203 patients whose best response was CR or PR, 83 patients discontinued pembrolizuma ...

タイトル: Identification of the α2 chain of interleukin-13 receptor as a potential biomarker for predicting castration resistance of prostate cancer using patient-derived xenograft models著者: Nagai, Takahiro; Terada, Naoki; Fujii, Masato; Nagata, Yasuhisa; Nakahara, Kozue; Mukai, Shoichiro; Okasho, Kosuke; Kamiyama, Yuki; Akamatsu, Shusuke; Kobayashi, Takashi; Iida, Kei; Denawa, Masatsugu; Hagiwara, Masatoshi; Inoue, Takahiro; Ogawa, Osamu; Kamoto, Toshiyuki抄録: Background: Several treatment strategies use upfront chemotherapy or androgen receptor axis-targeting therapies for metastatic prostate cancer. However, there are no useful biomarkers for selecting appropriate patients who urgently require these treatments.; Methods: Novel patient-derived xenograft (PDX) castration-sensitive and -resistant models were established and gene expression patterns were comprehensively compared. The function of a gene highly expressed in the castration-resistant models was evaluated by its ...

タイトル: Decomposition of mechanical stress effect on the magnetic property of silicon steel sheet著者: Shimizu, H.; Marumo, Y.; Mishima, Y.; Matsuo, T.抄録: A principal stress decomposition method was examined and compared with the equivalent stress theory to evaluate the stress-dependent magnetic properties of nonoriented silicon steel. A physical magnetization model, the multidomain particle model, was used to simulate the stress dependence of the magnetic properties by applying mechanical stress in different directions relative to the magnetic field direction. Experimental and computational tests show that even though the principal stress decomposition method provides a reasonable evaluation of the stress-dependent properties in the stress direction, it fails to accurately predict the properties in the perpendicular direction. To improve the prediction accuracy, a modified decomposition method is proposed, which gives a reasonable evaluation of the stress dependence of BH ...

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タイトル: Incidence and factors associated with newly implemented do-not-attempt-resuscitation orders among deteriorating patients after rapid response system activation: A retrospective observational study using a Japanese multicenter database著者: Tsuji, Tatsuya; Sento, Yoshiki; Nakanishi, Toshiyuki; Tamura, Tetsuya; Kako, Eisuke; Sato, Izumi; Kawakami, Koji; Kawasaki, Tatsuya; Naito, Takaki; Fujitani, Shigeki; Sobue, Kazuya抄録: [Aim] The rapid response system (RRS) was initially aimed to improve patient outcomes. Recently, some studies have implicated that RRS might facilitate do-not-attempt-resuscitation (DNAR) orders among patients, their families, and healthcare providers. This study aimed to examine the incidence and factors independently associated with DNAR orders newly implemented after RRS activation among deteriorating patients. [Methods] This observational study assessed patients who required RRS activation between 2012 and 2021 in Japan. We investigated patients' ...

タイトル: PBW theory for quantum affine algebras著者: Kashiwara, Masaki; Kim, Myungho; Oh, Se-jin; Park, Euiyong抄録: Let

タイトル: Review: Monitoring of land cover changes and plant phenology by remote‐sensing in East Asia著者: Shin, Nagai; Saitoh, M., Taku; Takeuchi, Yayoi; Miura, Tomoaki; Aiba, Masahiro; Kurokawa, Hiroko; Onoda, Yusuke; Ichii, Kazuhito; Nasahara, Nishida, Kenlo; Suzuki, Rikie; Nakashizuka, Tohru; Muraoka, Hiroyuki抄録: To achieve a sustainable society and solve the problems caused by climate change and socioeconomic activities, it is necessary to monitor the spatial and temporal variability of ecosystem functions, services, and biodiversity at both regional and global scales. During the last decade, we have seen rapid and significant improvement in satellite and near-surface remote-sensing technologies. In this review, we describe how remote-sensing observations are being used to effectively evaluate the spatial and temporal variability of land use and cover types and of plant phenology in East Asia. We discuss the current status, uncertainties, problems, and future perspecti ...