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タイトル: Systematic review and meta-analysis for the 2024 update of the Japan College of Rheumatology clinical practice guidelines for the management of rheumatoid arthritis著者: Nakayama, Yoichi; Nagata, Wataru; Takeuchi, Yoichi; Fukui, Sho; Fujita, Yuya; Hosokawa, Yohei; Ueno, Masanobu; Ono, Kumiko; Sumitomo, Shuji; Tabuchi, Yuya; Nakanishi, Yuichiro; Saito, Shuntaro; Ikeuchi, Hiroko; Kawamori, Kazutaka; Sofue, Hideaki; Doi, Goro; Minami, Runa; Hirota, Tomoya; Minegishi, Kaoru; Maeshima, Keisuke; Motoyama, Ryo; Nakamura, Shohei; Suzuki, Shotaro; Nishioka, Norihiro; Wada, Tsuzuki, Takuma; Onishi, Akira; Nishimura, Kenichi; Watanabe, Ryu; Yanai, Ryo; Kida, Takashi; Nishiwaki, Hiroki; Yajima, Nobuyuki; Kaneko, Yuko; Tanaka, Eiichi; Kawahito, Yutaka; Harigai, Masayoshi抄録: OBJECTIVES: The aim of this article is to update evidence on the efficacy and safety of disease-modifying antirheumatic drugs (DMARDs) and provide information to the taskforce for the 2024 update of the Japan ...

タイトル: PIONEER REAL Japan: Primary results from a multicenter, prospective, real-world study of oral semaglutide in adults with type 2 diabetes in Japanese clinical practice著者: Yabe, Daisuke; Hamamoto, Yoshiyuki; Kawanami, Daiji; Nishimura, Rimei; Terauchi, Yasuo; Amadid, Hanan; Braae, Uffe Christian; Major-Pedersen, Atheline; Suzuki, Ryo抄録: [Aims/Introduction] PIONEER REAL Japan was a non-interventional prospective study of oral semaglutide in adults with type 2 diabetes in Japanese clinical practice. [Materials and Methods] Adults naïve to injectable glucose-lowering therapies initiated oral semaglutide in routine clinical practice and were followed for 34–44 weeks. The primary endpoint was change in glycated hemoglobin (HbA₁c) from baseline to end of study; the co-primary endpoint was number of adverse events (AEs). Secondary endpoints included change in bodyweight from baseline to end of study. Analyses were also carried out for subgroups aged

タイトル: 京都大学附属図書館、大阪大学附属図書館及び神戸大学附属図書館の連携・協力活動におけるライブラリー・スキーマ検討の取り組み著者: 飯田, 智子; 石黒, 康太; 菊谷, 智史; 坂田, 絵理子; 田中, 志瑞子; 西川, 真樹子

タイトル: Sequential formation of supermassive stars and heavy seed BHs through the interplay of cosmological cold accretion and stellar radiative feedback著者: Kiyuna, Masaki; Hosokawa, Takashi; Chon, Sunmyon抄録: Supermassive stars (SMSs) and heavy seed black holes, as their remnants, are promising candidates for supermassive black hole (SMBH) progenitors, especially for ones observed in the early universe z≃8.5-10 by recent JWST observations. Expected cradles of SMSs are the atomic cooling haloes (Mₕₐₗₒ≃10⁷M[⊙]), where ‘cold accretion’ emerges and possibly forms SMSs. We perform a suit of cosmological radiation hydrodynamics simulations and investigate star formation after the emergence of cold accretion, solving radiative feedback from stars inside the halo. We follow the mass growth of the protostars for ~3Myr, resolving the gas inflow down to ~0.1 pc scales. We discover that, after cold accretion emerges, multiple SMSs of m[⋆]≳10⁵M[⊙] form at t ...

タイトル: Impacts of building modifications on the turbulent flow and heat transfer in urban surface boundary layers著者: Tanji, Seika; Takemi, Tetsuya; Duan, Guangdong抄録: This study examines turbulent airflow and upward heat transport in real urban environments using a building-resolving large-eddy simulation model to understand the characteristics of turbulent airflow and upward heat transport when geometrical distributions of buildings are modified. The target areas were two real urban districts within Osaka City, Japan, having different morphological features. In the numerical experiments, the initial condition was set to a neutral condition in which temperature is uniformly distributed vertically, and buildings emitted heat at a constant rate. The results in the two districts indicated that the features of turbulence and heat transport distinctly differed with different building arrangement. Specifically, taller buildings significantly decelerated airflows and induced wa ...

タイトル: Temperament in Early Childhood Is Associated With Gut Microbiota Composition and Diversity著者: Ueda, Eriko; Matsunaga, Michiko; Fujihara, Hideaki; Kajiwara, Takamasa; Takeda, K., Aya; Watanabe, Satoshi; Hagihara, Keisuke; Myowa, Masako抄録: Temperament is a key predictor of human mental health and cognitive and emotional development. Although human fear behavior is reportedly associated with gut microbiome in infancy, infant gut microbiota changes dramatically during the first 5 years, when the diversity and composition of gut microbiome are established. This period is crucial for the development of the prefrontal cortex, which is involved in emotion regulation. Therefore, this study investigated the relationship between temperament and gut microbiota in 284 preschool children aged 3–4 years. Child temperament was assessed by maternal reports of the Children's Behavior Questionnaire. Gut microbiota (alpha/beta diversity and genera abundance) was evaluated using 16S ...

タイトル: Two Aramaic Piyyutim from the Second Crusade (1148)著者: Katsumata, Naoya; Wout, van Bekkum抄録: A single folio from MS 119 in the Geneva Genizah includes two unknown and unpublished piyyutim in Aramaic, which are presented in this study for the first time. The two hymns can be precisely dated to the year 1148, the time of the Second Crusade. They resemble each other to a significant extent in terms of content and prosody, referring to a dire historical situation that can be explicitly linked to the siege of Damascus in the summer of 1148. This study presents a critical edition of the two Aramaic piyyutim together with an English translation alongside other textual elements within the remarkable context of this unique folio.

タイトル: Dataset for the paper Impact of Charge Distribution on the Stability of Ferroelectric Nematic Liquid Crystals著者: Matheus, de Mello

タイトル: Additional treatments after curettage of congenital melanocytic nevi in the craniofacial region: Areport from a single center in Japan.著者: Masuno, Haruko; Sakamoto, Michiharu; Katayama, Yasuhiro; Yamanaka, Hiroki; Tsuge, Itaru; Katsube, Motoki; Saito, Susumu; Morimoto, Naoki抄録: Background: Congenital melanocytic nevus (CMN) is a benign skin lesion present from birth, which may present with a risk of malignant transformation if extensive. Curettage, a treatment method involving the removal of the superficial layer of the nevus, is often used in the early stages of life. However, recurrence of the nevus and postoperative scarring may present as problems. Additional treatments, such as resection and/or laser treatment, are regularly required after curettage, particularly in the craniofacial region. However, no systematic treatment strategy has been reported. This study investigated additional treatments used after curettage to treat CMN in the craniofacial region and ...

タイトル: Tadalafil use is associated with a lower incidence of Type 2 diabetes in men with benign prostatic hyperplasia: A population-based cohort study著者: Takayama, Atsushi; Yoshida, Satomi; Kawakami, Koji抄録: BACKGROUND: Tadalafil, commonly prescribed for benign prostatic hyperplasia (BPH), may benefit patients with Type 2 diabetes mellitus (T2DM) for glycemic markers and complications. However, the association between the long-term use of tadalafil and the incidence of T2DM has not been investigated. METHODS: We emulated a target trial of tadalafil use (5 mg/day) and the risk of T2DM using a population-based claims database in Japan. Patients who initiated tadalafil or alpha-blockers for BPH and had no history of diabetes diagnosis, no dispensing of glucose-lowering drugs, and no history of hemoglobin A1c levels of ≥6.5% (47–48 mmol/mol) were included. The primary outcome was the incidence of T2DM. Pooled logistic regression was used to estimate adjusted risk ratios ...