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Autumn offers us an opportunity to contemplate our own mortality

If you don’t have the time to attend the best tasting events, a wine club may be for you. But what do you get for your money?

How a 1960s block of towers filled with dealmakers and refugees came to define the changing city

Six decades after the first bullet train left Tokyo Station, Leo Lewis celebrates an icon of speed, style and national identity

No other place on earth has witnessed more cycles of conflict and forced migration

After helping to undo the postwar consensus, he became Britain’s man in Washington DC

The controversial move on Commerzbank would be the first big cross-border deal in Europe since the financial crisis

Departure of chief technology officer Mira Murati ensures ChatGPT-maker’s chief executive is now surrounded by allies

To solve its housing crisis, Britain needs to start planning again — and rekindle the urban idealism of the postwar decades 

タイトル: Blockade of Crk eliminates Yki/YAP-activated tumors via JNK-mediated apoptosis in Drosophila著者: Kakemura, Bungo; Igaki, Tatsushi抄録: Selective elimination of cancer cells without causing deleterious effects on normal cells is an ideal anti-cancer strategy. Here, using Drosophila cancer model, we performed an in vivo RNAi screen for anti-cancer targets that selectively eliminate tumors without affecting normal tissue growth. In Drosophila imaginal epithelium, clones of cells expressing oncogenic Ras with simultaneous mutations in the cell polarity gene scribble ([V12]Ras/[-/-]scrib) develop into malignant tumors. We found that knockdown of Crk, the Drosophila ortholog of human CRK (CT10 regulatory kinase) and CRKL (Crk-like) adapter proteins, significantly suppresses growth of [V12]Ras/[-/-]scrib tumors by inducing c-Jun N-terminal kinase (JNK)-mediated apoptosis, while it does not affect growth of normal epithelium. Mechanistically, Crk inhibition blocks Yorkie (Yk ...