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タイトル: Multiscale chemogenetic dissection of fronto-temporal top-down regulation for object memory in primates著者: Hirabayashi, Toshiyuki; Nagai, Yuji; Hori, Yuki; Hori, Yukiko; Oyama, Kei; Mimura, Koki; Miyakawa, Naohisa; Iwaoki, Haruhiko; Inoue, Ken-ichi; Suhara, Tetsuya; Takada, Masahiko; Higuchi, Makoto; Minamimoto, Takafumi抄録: Visual object memory is a fundamental element of various cognitive abilities, and the underlying neural mechanisms have been extensively examined especially in the anterior temporal cortex of primates. However, both macroscopic large-scale functional network in which this region is embedded and microscopic neuron-level dynamics of top-down regulation it receives for object memory remains elusive. Here, we identified the orbitofrontal node as a critical partner of the anterior temporal node for object memory by combining whole-brain functional imaging during rest and a short-term object memory task in male macaques. Focal chemogenetic silencing ...

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