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From money-saving work perks to investments and tax planning, resolve to get your finances in shape this new year

On both sides of Atlantic, most surveyed claim protectionist shift will overshadow benefits of other policies

タイトル: Identification and structure-guided development of triazole urea-based selective antagonists of Arabidopsis karrikin signaling著者: Wang, Jianwen; Takahashi, Ikuo; Kikuzato, Ko; Sakai, Toshihiko; Zhu, Zhangliang; Jiang, Kai; Nakamura, Hidemitsu; Nakano, Takeshi; Tanokura, Masaru; Miyakawa, Takuya; Asami, Tadao抄録: The smoke-derived butenolides, karrikins (KARs), regulate many aspects of plant growth and development. However, KARs and a plant hormone, strigolactones (SLs), have high resemblance in signal perception and transduction, making it hard to delineate KARs response due to the shortage of chemical-genetic tools. Here, we identify a triazole urea KK181N1 as an inhibitor of the KARs receptor KAI2. KK181N1 selectively depress the KAR-induced phenotypes in Arabidopsis. We further elucidate the antagonistic, KAI2 binding mechanism of KK181N1, showing that KK181N1 binds to the catalytic pockets of KAI2 in a non-covalent binding manner. Our experiments also demonstra ...

Isis flag found on vehicle used in deadly attack and suspect named as US-born military veteran from Texas

‘MiniLife’ research extends growing field of synthetic biology into new territory

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Group emerges as crucial backer of start-ups seeking to gain from the tech revolution its chips are powering

Risk-averse financial institutions concentrate money on biggest Silicon Valley VCs in trend that threatens smaller groups

Voters can’t be sold on change until their nation is in acute trouble

Mass, cross-generational audiences have disappeared and even MrBeast can’t find them