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To solve its housing crisis, Britain needs to start planning again — and rekindle the urban idealism of the postwar decades 

タイトル: Blockade of Crk eliminates Yki/YAP-activated tumors via JNK-mediated apoptosis in Drosophila著者: Kakemura, Bungo; Igaki, Tatsushi抄録: Selective elimination of cancer cells without causing deleterious effects on normal cells is an ideal anti-cancer strategy. Here, using Drosophila cancer model, we performed an in vivo RNAi screen for anti-cancer targets that selectively eliminate tumors without affecting normal tissue growth. In Drosophila imaginal epithelium, clones of cells expressing oncogenic Ras with simultaneous mutations in the cell polarity gene scribble ([V12]Ras/[-/-]scrib) develop into malignant tumors. We found that knockdown of Crk, the Drosophila ortholog of human CRK (CT10 regulatory kinase) and CRKL (Crk-like) adapter proteins, significantly suppresses growth of [V12]Ras/[-/-]scrib tumors by inducing c-Jun N-terminal kinase (JNK)-mediated apoptosis, while it does not affect growth of normal epithelium. Mechanistically, Crk inhibition blocks Yorkie (Yk ...

Biggest attack on Lebanese capital in offensive said to have targeted group’s commander, Hassan Nasrallah

Comcast unit says missing out on ‘irreplaceable’ series could cost it hundreds of millions of dollars

Anura Kumara Dissanayake won election on promises to challenge IMF deal, cut taxes and crack down on corruption

Germany, France and Netherlands not ready for biometric system due to start in November

Rachel Reeves is looking at loosening fiscal rules to allow her to increase borrowing to pay for investment

Bumble and Match Group launch friendship and social products to help reverse post-pandemic slowdown

Current rules hem the chancellor in — this Budget can make a start on ways to attract and measure investment

Pressure grows after the UK’s PM and some senior colleagues come under fire over donations from a Labour peer