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タイトル: Delivery management of pregnant blue rubber bleb nevus syndrome patients: a case report and literature review著者: Nagahama, Mie; Chigusa, Yoshitsugu; Shiraki, Atsuko; Takei, Yui; Yamaguchi, Ayaka; Mizota, Toshiyuki; Komatsu, Maya; Nomura, Takashi; Egi, Moritoki; Mandai, Masaki; Mogami, Haruta抄録: Blue rubber bleb nevus syndrome (BRBNS) is a rare systemic vascular disorder characterized by multifocal venous malformations (VMs). Little is known about the perinatal management of pregnant women with BRBNS owing to the limited number of reported cases. We present the case of a 36-year-old primigravida with BRBNS who underwent an uneventful cesarean section under spinal anesthesia for breech presentation. A thorough systemic examination revealed VMs in various organs, including the skin, conjunctiva, larynx, gastrointestinal tract, lungs, and vulva. Prior to spinal anesthesia, careful examination using imaging modalities was conducted to assess the spinal and epidural inv ...

タイトル: PRDX6 augments selenium utilization to limit iron toxicity and ferroptosis著者: Fujita, Hiroaki; Tanaka, Yu-Ki; Ogata, Seiryo; Suzuki, Noriyuki; Kuno, Sota; Barayeu, Uladzimir; Akaike, Takaaki; Ogra, Yasumitsu; Iwai, Kazuhiro抄録: Ferroptosis is a form of regulated cell death induced by iron-dependent accumulation of lipid hydroperoxides. Selenoprotein glutathione peroxidase 4 (GPX4) suppresses ferroptosis by detoxifying lipid hydroperoxides via a catalytic selenocysteine (Sec) residue. Sec, the genetically encoded [st]21 amino acid, is biosynthesized from a reactive selenium donor on its cognate [[Ser]Sec]tRNA. It is thought that intracellular selenium must be delivered ‘safely’ and ‘efficiently’ by a carrier protein owing to its high reactivity and very low concentrations. Here, we identified peroxiredoxin 6 (PRDX6) as a novel selenoprotein synthesis factor. Loss of PRDX6 decreases the expression of selenoproteins and induces ferroptosis via a reduction in G ...

タイトル: 取得資格など (2023年度)

タイトル: Jamie S. Davidson, ed. Just Another Crisis? The Impact of the COVID-19 Pandemic on Southeast Asia's Rice Sector. Singapore: ISEAS - Yusof Ishak Institute, 2023.著者: Matsuda, Masahiko

タイトル: Anoma P. van der Veere, Florian Schneider, and Catherine Yuk-ping Lo, eds. Public Health in Asia during the COVID-19 Pandemic: Global Health Governance, Migrant Labour, and International Health Crises. Amsterdam: Amsterdam University Press, 2022.著者: Latif, Muhammad Asad

タイトル: Bérénice Bellina, Roger Blench, and Jean-Christophe Galipaud, eds. Sea Nomads of Southeast Asia: From the Past to the Present. Singapore: NUS Press, 2021.著者: Ariando, Wengki; Arunotai, Narumon

タイトル: Road to extinction: Archival samples unveiled the process of inbreeding depression during artificial breeding in an almost extinct butterfly species著者: Nakahama, Naoyuki; Konagaya, Tatsuro; Ueda, Shouhei; Hirai, Norio; Yago, Masaya; Yaida, Yuki A.; Ushimaru, Atushi; Isagi, Yuji抄録: During ex-situ conservation of endangered species, reproductive disruption risk due to inbreeding depression increases when genetic diversity is reduced due to founder effects or population declines. Elucidating the population genetic process of reproductive disruption will help understand the risks and mechanisms associated with inbreeding depression. A comprehensive understanding of these processes would require a comparison of reproductive traits and genetic diversity in the populations of endangered species that have experienced reproductive disruption. However, such previous studies, which focus on endangered species, are limited. Ex-situ conservation was initiated for the Ogasawara ...

タイトル: Sex chromosome cycle as a mechanism of stable sex determination著者: Hayashi, Shun; Abe, Takuya; Igawa, Takeshi; Katsura, Yukako; Kazama, Yusuke; Nozawa, Masafumi抄録: Recent advances in DNA sequencing technology have enabled the precise decoding of genomes in non-model organisms, providing a basis for unraveling the patterns and mechanisms of sex chromosome evolution. Studies of different species have yielded conflicting results regarding the traditional theory that sex chromosomes evolve from autosomes via the accumulation of deleterious mutations and degeneration of the Y (or W) chromosome. The concept of the ‘sex chromosome cycle, ’ emerging from this context, posits that at any stage of the cycle (i.e., differentiation, degeneration, or loss), sex chromosome turnover can occur while maintaining stable sex determination. Thus, understanding the mechanisms that drive both the persistence and turnover of sex chromosomes at each stage of the cycle is crucial. In ...

タイトル: 大規模言語モデルは人間の言語能力の解明に役立つのか?(後編)著者: 瀧川, 一学; 折田, 奈甫記述: ［連載］人間の言語能力とは何か--生成文法からの問い 番外編 2; 本連載第 2 回（2023 年 12 月号）の指定討論者である岡野原氏と瀧川氏は編訳者の一人である折田氏と，掲載した論考以外にメールでの議論も行った。; 前回に続き，番外編 2 としてその議論を収録する。

タイトル: Talking Like Opposition Parties? Electoral Proximity and Language Styles Employed by Coalition Partners in a Mixed Member Majoritarian System著者: Ishima, Hideo抄録: Extant literature has shown that political parties that form a coalition government face one major dilemma; that is, they must govern together but fight elections separately. Thus, coalition members tend to commit to a differentiated strategy as an election approaches. However, existing research has mainly focused on empirical findings from countries with proportional representation and few measures for direct criticism from partners. In order to test the theory, this study examines parliamentary speeches from Japan’s mixed member majoritarian context. It uses a supervised machine learning method for measuring confrontational attitudes toward governments irrespective of their ideologies. The results of this study show that on average, while a coalition partner may present a slightly hostile attitude tow ...