リンク集 RSS/ATOM 記事

Title: Information geometric bound on general chemical reaction networksAuthors: Mizohata, Tsuyoshi; Kobayashi, Tetsuya J.; Bouchard, Louis-S.; Miyahara, HideyukiAbstract: We investigate the convergence of chemical reaction networks (CRNs), aiming to establish an upper bound on their reaction rates. The nonlinear characteristics and discrete composition of CRNs pose significant challenges in this endeavor. To circumvent these complexities, we adopt an information geometric perspective, utilizing the natural gradient to formulate a nonlinear system. This system effectively determines an upper bound for the dynamics of CRNs. We corroborate our methodology through numerical simulations, which reveal that our constructed system converges more rapidly than CRNs within a particular class of reactions. This class is defined by the count of chemicals, the highest stoichiometric coefficients in the reactions, and the total number of reactions involved. Further, we juxtapose our approach with tr ...

2024年3月の月間アクセスランキングを掲載しました。

UK-based lender to sell business to Grupo Financiero Galicia for $550mn as it exits market racked with hyperinflation

タイトル: Predicting attitudes toward ambiguity using natural language processing on free descriptions for open-ended question measurements著者: Hitsuwari, Jimpei; Okano, Hirohito; Nomura, Michio抄録: Individual traits and reactions to ambiguity differ and are conceptualized in terms of an individual's attitudes toward ambiguity or ambiguity tolerance. The development of natural language processing technology has made it possible to measure mental states and reactions through open-ended questions, rather than predefined numerical rating scales, which have traditionally been the dominant method in psychological research. This study presented three ambiguity-related situations and responses collected online from 591 participants in an open-ended format. After the analysis with bidirectional encoder representations from transformers, correlations were calculated using scores from the numerical evaluation by conventional questionnaire, and a significant moderate positive correlatio ...

タイトル: Micro-patterned culture of iPSC-derived alveolar and airway cells distinguishes SARS-CoV-2 variants.著者: Masui, Atsushi; Hashimoto, Rina; Matsumura, Yasufumi; Yamamoto, Takuya; Nagao, Miki; Noda, Takeshi; Takayama, Kazuo; Gotoh, Shimpei抄録: The emergence of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) variants necessitated a rapid evaluation system for their pathogenesis. Lung epithelial cells are their entry points; however, in addition to their limited source, the culture of human alveolar epithelial cells is especially complicated. Induced pluripotent stem cells (iPSCs) are an alternative source of human primary stem cells. Here, we report a model for distinguishing SARS-CoV-2 variants at high resolution, using separately induced iPSC-derived alveolar and airway cells in micro-patterned culture plates. The position-specific signals induced the apical-out alveolar type 2 and multiciliated airway cells at the periphery and center of the colonies, re ...

タイトル: Adenosine triphosphate induces amorphous aggregation of amyloid β by increasing Aβ dynamics著者: Kuramochi, Masahiro; Nakamura, Momoka; Takahashi, Hiroto; Komoriya, Tomoe; Takita, Teisuke; Pham, Ngan Thi Kim; Yasukawa, Kiyoshi; Yoshimune, Kazuaki抄録: Amyloid β (Aβ) aggregates into two distinct fibril and amorphous forms in the brains of patients with Alzheimer’s disease. Adenosine triphosphate (ATP) is a biological hydrotrope that causes Aβ to form amorphous aggregates and inhibit fibril formation at physiological concentrations. Based on diffracted X-ray blinking (DXB) analysis, the dynamics of Aβ significantly increased immediately after ATP was added compared to those in the absence and presence of ADP and AMP, and the effect diminished after 30 min as the aggregates formed. In the presence of ATP, the β-sheet content of Aβ gradually increased from the beginning, and in the absence of ATP, the content increased rapidly after 180 min incubation, as reveal ...

大学院、大学、短期大学部の入学式は５日、建学記念講堂で行われました。 大学院修士課程３名、大学の生活科学科29名、食物栄養学科47名、３年次編入７名、短大の健康栄養学科36名、幼児教育学科85名、地域創成学科62名、専攻科14名の合わせて283名がそれぞれの夢を目指して学びの門をたたきました。 関口修学長が告辞を述べ「尊敬・責任・自由の建学の精神を理解し、社会から望まれる人となれるよう自分を磨いてください」と激励。来賓や附属高校・幼稚園の代表に次いで、在学生代表の柏木美知さん（幼児教育学科２年）が祝辞を送りました。 新入生を代表して鈴木千尋さん（地域創成学科）が「知識や教養だけでなく他との協調性を育み、社会へ貢献できる女性になれるようたゆまぬ努力を続けます」と誓いました。 入学式を ...

2024年04月03日 ワクチン情報2023年05月02日 新型コロナウイルス感染症対策のお願い（5月8日以降）2023年03月10日 マスク着用について2022年09月22日 新型コロナウイルスに感染したときの対応について

タイトル: A comprehensive approach to characterize navigation instruments for magnetic guidance in biological systems著者: Blümler, Peter; Raudzus, Fabian; Schmid, Friederike抄録: Achieving non-invasive spatiotemporal control over cellular functions, tissue organization, and behavior is a desirable aim for advanced therapies. Magnetic fields, due to their negligible interaction with biological matter, are promising for in vitro and in vivo applications, even in deep tissues. Particularly, the remote manipulation of paramagnetic (including superparamagnetic and ferromagnetic, all with a positive magnetic susceptibility) entities through magnetic instruments has emerged as a promising approach across various biological contexts. However, variations in the properties and descriptions of these instruments have led to a lack of reproducibility and comparability among studies. This article addresses the need for standardizing the characterization of magnetic instruments, with a spec ...

タイトル: Microfluidic Device for Simple Diagnosis of Plant Growth Condition by Detecting miRNAs from Filtered Plant Extracts著者: Kawakatsu, Yaichi; Okada, Ryo; Hara, Mitsuo; Tsutsui, Hiroki; Yanagisawa, Naoki; Higashiyama, Tetsuya; Arima, Akihide; Baba, Yoshinobu; Kurotani, Ken-ichi; Notaguchi, Michitaka抄録: Plants are exposed to a variety of environmental stress, and starvation of inorganic phosphorus can be a major constraint in crop production. In plants, in response to phosphate deficiency in soil, miR399, a type of microRNA (miRNA), is up-regulated. By detecting miR399, the early diagnosis of phosphorus deficiency stress in plants can be accomplished. However, general miRNA detection methods require complicated experimental manipulations. Therefore, simple and rapid miRNA detection methods are required for early plant nutritional diagnosis. For the simple detection of miR399, microfluidic technology is suitable for point-of-care applications because of its ability to de ...