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Treasury chief secretary Darren Jones launches line-by-line assessment to find 5% savings

US investment group had been in exclusive talks to buy office building for about £300mn

The end of the US-led order is giving way to a kind of chaos that chimes with the president-elect’s preferences

London landlord has no major debts due before 2028 after securing £2bn of headroom in transactions this year

In his first year, the libertarian president has stabilised a turbulent economy, while retaining the support of half the population. But big challenges loom

１２月５日（木）、家庭寮食堂にて寮友会主催のクリスマス会を開催しました。 家庭寮では、１０月に役員改選を行い、新役員にとっては初めて運営する行事となりました。 今年度のクリスマス会は、昨年に引き続きチョコレートフォンデュです。 今回のクリスマス会は、新旧役員が一緒に計画を立てました。予想を超える参加希望者が集まり、クリスマス会は３部制で開催しました。 参加者全員にチョコレートフォンデュを楽しんでもらうため、受付時にチョコレートフォンデュセットとして、いちご、キウイ、バナナ、パイナップル、マシュマロ、ミニシュークリームを配布しました。 また、食材の持参も可能にしたため、当日はにぎやかなクリスマス会になりました。

タイトル: UGGT1-mediated reglucosylation of N-glycan competes with ER-associated degradation of unstable and misfolded glycoproteins著者: Ninagawa, Satoshi; Matsuo, Masaki; Ying, Deng; Oshita, Shuichiro; Aso, Shinya; Matsushita, Kazutoshi; Taniguchi, Mai; Fueki, Akane; Yamashiro, Moe; Sugasawa, Kaoru; Saito, Shunsuke; Imami, Koshi; Kizuka, Yasuhiko; Sakuma, Tetsushi; Yamamoto, Takashi; Yagi, Hirokazu; Kato, Koichi; Mori, Kazutoshi抄録: How the fate (folding versus degradation) of glycoproteins is determined in the endoplasmic reticulum (ER) is an intriguing question. Monoglucosylated glycoproteins are recognized by lectin chaperones to facilitate their folding, whereas glycoproteins exposing well-trimmed mannoses are subjected to glycoprotein ER-associated degradation (gpERAD); we have elucidated how mannoses are sequentially trimmed by EDEM family members (George et al., 2020; 2021 eLife). Although reglucosylation by UGGT was previously reported to have no effect on substrate ...

Media mogul’s attempt to put control of his news empire in son Lachlan’s hands is rejected by Nevada court

HTS issues amnesty for conscripted military but Israel grabs territory on border