リンク集 RSS/ATOM 記事

タイトル: The Anabelian Geometry of Configuration Spaces of Hyperbolic Curves in Positive Characteristic著者: HOSHI, Yuichiro; SAWADA, Koichiro; TSUJIMURA, Shota抄録: In the present paper, we prove the anabelian Grothendieck conjecture for the tame fundamental groups of the configuration spaces associated to hyperbolic curves over [the perfections of] finitely generated fields of positive characteristic. The main theorem of the present paper generalizes the classical anabelian results for hyperbolic curves in positive characteristic established by A. Tamagawa, S. Mochizuki, and J. Stix. The main theorem of the present paper may also be regarded as the first anabelian Grothendieck conjecture-type result for algebraic varieties in positive characteristic of higher dimension [i.e., of dimension greater than one]. In the process of the proof of the main theorem, we prove a certain exactness of homotopy sequences for the tame fundamental groups with respect to suitable morphisms bet ...

タイトル: Profile of miRNAs in small extracellular vesicles released from glioblastoma cells treated by boron neutron capture therapy著者: Kondo, Natsuko; Kinouchi, Tadatoshi; Natsumeda, Manabu; Matsuzaki, Juntaro; Hirata, Eishu; Sakurai, Yoshinori; Okada, Masayasu; Suzuki, Minoru抄録: Purpose: Boron neutron capture therapy (BNCT) is a tumor cell-selective particle-radiation therapy. In BNCT, administered p-boronophenylalanine (BPA) is selectively taken up by tumor cells, and the tumor is irradiated with thermal neutrons. High-LET α-particles and recoil ⁷Li, which have a path length of 5–9 μm, are generated by the capture reaction between ¹⁰B and thermal neutrons and selectively kill tumor cells that have uptaken ¹⁰B. Although BNCT has prolonged the survival time of malignant glioma patients, recurrences are still to be resolved. miRNAs, that are encapsulated in small extracellular vesicles (sEVs) in body fluids and exist stably may serve critical role in recurrence ...

タイトル: The unique contribution of handwriting accuracy to literacy skills in Japanese adolescents著者: Otsuka, Sadao; Murai, Toshiya抄録: There is widespread concern about declining literacy skills in recent young Japanese. The present study investigated how higher-level reading and writing proficiencies are underpinned by basic literacy skills in Japanese adolescents. From a large database of the most popular literacy exams in Japan, we retrospectively analyzed word- and text-level data for middle and high school students who had taken the exams during the same period in the 2019 academic year using structural equation modeling. We extracted main data for 161 students as well as six independent datasets for validation. Our results validated the three-dimensional view of word-level literacy (reading accuracy, writing accuracy, and semantic comprehension) and demonstrated that writing and semantic skills underpinned text writing and reading, respectively. The semantic compreh ...

タイトル: Characteristics of Acute Cartilage Response After Mechanical Loading in Patients with Early-Mild Knee Osteoarthritis著者: Okada, Shogo; Taniguchi, Masashi; Yagi, Masahide; Motomura, Yoshiki; Okada, Sayaka; Nakazato, Kaede; Fukumoto, Yoshihiro; Kobayashi, Masashi; Kanemitsu, Kyoseki; Ichihashi, Noriaki抄録: This study determined whether the acute cartilage response, assessed by cartilage thickness and echo intensity, differs between patients with early-mild knee osteoarthritis (OA) and healthy controls. We recruited 56 women aged ≥ 50 years with Kellgren-Lawrence (KL) grade ≤ 2 (age, 70.6 ± 7.4 years; height, 153.7 ± 5.2 cm; weight, 51.9 ± 8.2 kg). Based on KL grades and knee symptoms, the participants were classified into control (KL ≤ 1, asymptomatic, n = 27) and early-mild knee OA groups (KL 1 and symptomatic, KL 2, n = 29). Medial femoral cartilage thickness and echo intensity were assessed using ultrasonographic B-mode imag ...

タイトル: The RNA-binding protein Msi2 regulates autophagy during myogenic differentiation著者: Wang, Ruochong; Kato, Futaba; Watson, Rio Yasui; Beedle, Aaron M; Call, Jarrod A; Tsunoda, Yugo; Noda, Takeshi; Tsuchiya, Takaho; Kashima, Makoto; Hattori, Ayuna; Ito, Takahiro抄録: Skeletal muscle development is a highly ordered process orchestrated transcriptionally by the myogenic regulatory factors. However, the downstream molecular mechanisms of myogenic regulatory factor functions in myogenesis are not fully understood. Here, we identified the RNA-binding protein Musashi2 (Msi2) as a myogenin target gene and a post-transcriptional regulator of myoblast differentiation. Msi2 knockdown in murine myoblasts blocked differentiation without affecting the expression of MyoD or myogenin. Msi2 overexpression was also sufficient to promote myoblast differentiation and myocyte fusion. Msi2 loss attenuated autophagosome formation via down-regulation of the autophagic protein MAPL1LC3/ATG8 ...

タイトル: Oxidative phosphorylation is a pivotal therapeutic target of fibrodysplasia ossificans progressiva著者: Sun, Liping; Jin, Yonghui; Nishio, Megumi; Watanabe, Makoto; Kamakura, Takeshi; Nagata, Sanae; Fukuda, Masayuki; Maekawa, Hirotsugu; Kawai, Shunsuke; Yamamoto, Takuya; Toguchida, Junya抄録: Heterotopic ossification (HO) is a non-physiological bone formation where soft tissue progenitor cells differentiate into chondrogenic cells. In fibrodysplasia ossificans progressiva (FOP), a rare genetic disease characterized by progressive and systemic HO, the Activin A/mutated ACVR1/mTORC1 cascade induces HO in progenitors in muscle tissues. The relevant biological processes aberrantly regulated by activated mTORC1 remain unclear, however. RNA-sequencing analyses revealed the enrichment of genes involved in oxidative phosphorylation (OXPHOS) during Activin A–induced chondrogenesis of mesenchymal stem cells derived from FOP patient–specific induced pluripotent stem cells. F ...

タイトル: Kinetic Analysis of Active Omni Wheel With Barrel-Shaped Rollers for Avoiding Slippage and Vibration著者: Long, Siying; Terakawa, Tatsuro; Yogou, Mahiro; Koyano, Rintaro; Komori, Masaharu抄録: Omnidirectional mobility is required for the efficient movement of transport vehicles in factories and warehouses. To meet this requirement, the active omni wheel with barrel-shaped rollers (AOWBR) was previously proposed. The barrel-shaped rollers are arranged around the outer circumference of the main wheel of the AOWBR. This structure is expected to be effective in suppressing vibration during vehicle movement. The transmission roller drives the outer roller via a friction drive, which actively moves the AOWBR in the lateral direction. However, the friction drive may cause slippage between the transmission roller and the outer roller. To solve this problem, this study investigates the effects of the design parameters for an AOWBR on vibration and wheel slippage. The kinetic m ...

4月2日～3日には学内オリエンテーション、4月24日からは学外オリエンテーションとして一泊二日の宿泊研修がホテル「メルキュール裏磐梯リゾート＆スパ」で実施されました。学外での宿泊研修は、コロナ禍により4年ぶりの開催です。 副学長による講話や学科別研修が計画され、学科別研修では五色沼入口散策や美術館見学等も行い、自然豊かな環境の中で教員と学生の親睦が図られました。 第1班 副学長による講話の様子 第２班 副学長による講話の様子

Legislation will face tough challenge in the senate as libertarian president seeks to advance his agenda

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