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UK prime minister writes in FT that Labour government will not become addicted to tax and spend

If we want the country to grow again, then we need to get it working and building again

タイトル: Molecular mechanism of parental H3/H4 recycling at a replication fork著者: Nagae, Fritz; Murayama, Yasuto; Terakawa, Tsuyoshi抄録: In chromatin replication, faithful recycling of histones from parental DNA to replicated strands is essential for maintaining epigenetic information across generations. A previous experiment has revealed that disrupting interactions between the N-terminal tail of Mcm2, a subunit in DNA replication machinery, and a histone H3/H4 tetramer perturb the recycling. However, the molecular pathways and the factors that regulate the ratio recycled to each strand and the destination location are yet to be revealed. Here, we performed molecular dynamics simulations of yeast DNA replication machinery, an H3/H4 tetramer, and replicated DNA strands. The simulations demonstrated that histones are recycled via Cdc45-mediated and unmediated pathways without histone chaperones, as our in vitro biochemical assays supported. Also, RPA binding regulated the ra ...

Comments spark new row over Republican’s language about political opponents

Investment valuing market information provider at about $500mn would be the sector’s latest high-profile deal

Articles alleging what Hamas was planning in Gaza appeared in British and German newspapers, sparking investigation

October figure far below average forecast of 100,000 job gains and comes just four days before US election

Clip purporting to show a Haitian voting in Georgia is among ‘Moscow’s broader efforts’ to sway the race, intelligence agencies say

Move to target wealthy foreigners comes as government makes several concessions to stem flow out of Britain

A historically tight presidential race might not be over on the night — and multiple crises could follow