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タイトル: Identification of meibomian gland testosterone metabolites produced by tissue-intrinsic intracrine deactivation activity著者: Nguyen Pham, Khanh Tien; Miyake, Takahito; Suzuki, Tomo; Kinoshita, Shigeru; Hamada, Yuki; Uehara, Hikari; Machida, Mamiko; Nakajima, Takeshi; Hasegawa, Emi; Doi, Masao抄録: Intracrinology--wherein hormones are synthesized in the organ where they exert their effect without release into circulation--has been described. However, molecular mechanisms of hormone deactivation within intracrine tissue are still largely unknown. The meibomian glands in the eyelids produce oil (meibum) to the ocular surface to prevent dehydration (dry eye). Androgens are generated inside this gland and are crucial for its tissue-homeostasis. However, there is no data showing the presence of androgens in meibum, implying local conversion/deactivation into unknown metabolites. Here, we performed radioactive tracer studies in combination with pharmacological enzyme inhibi ...

タイトル: 意味不明さを主張する聞き返しとその相互⾏為上の働き: 「は？」の会話分析著者: 阪上, 芽以抄録: 本稿は、日常の自然会話における短い発話表現が情報伝達以上に豊かな役割を担っていることに着目し、具体的な相互行為上の役割を分析した研究である。従来、「は？」は辞書的に「感動詞」あるいは「聞き返し」として説明されてきたが、こうした説明ではその多面的な役割を十分に捉えきれない点に問題意識を持った。本研究では自然発生会話データを用いて、「は？」が「意味不明さ」を主張することで、修復を促す場面、対立を強調する場面、歩調を合わせる場面という三つの局面で異なる相互行為上の働きを担うことを示した。重要なのは、「は？」自体に三種類の用法が内在するのではなく、話者が前後の連鎖環境に ...

タイトル: 1 Hz dynamical strain waves during the 2011 Tohoku Mw9.0 earthquake from high-rate GNSS著者: Xu, Peiliang記述: This set of movie files is generated by this author with the GEONET GPS raw data provided by the Geospatial Information Authority (GSI) of Japan

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