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by Immaculate Kambutse, Grace Igiraneza, Sheela Shenoi, Onyema Ogbuagu

by Kelly K. Ferguson, Thomas F. McElrath, Bhramar Mukherjee, Rita Loch-Caruso, John D. Meeker

by Vladimir Isachenko, Plamen Todorov, Evgenia Isachenko, Gohar Rahimi, Andrey Tchorbanov, Nikolina Mihaylova, Iliyan Manoylov, Peter Mallmann, Markus Merzenich

by Amanda L. Ziegler, Tiffany A. Pridgen, Juliana K. Mills, Liara M. Gonzalez, Laurianne Van Landeghem, Jack Odle, Anthony T. Blikslager

by Nina M. Molenaar, Marlies E. Brouwer, Astrid M. Kamperman, Huibert Burger, Alishia D. Williams, Witte J. G. Hoogendijk, Claudi L. H. Bockting, Mijke P. Lambregtse-van den Berg Objective Antidepressant medication is commonly used for the prevention of depression recurrence in the perinatal period, yet it is unknown what vulnerability markers may play a role in recurrence. The objective of the current study was to provide a descriptive overview of the associated characteristics of women who experienced a perinatal recurrence of depression despite ongoing antidepressant use, and further, to identify clinically measurable vulnerability markers associated with recurrence. Methods Eighty-five pregnant women with a history of depression who used antidepressants (e.g. Selective Serotonin Reuptake Inhibitors or Serotonin and Noradrenaline Reuptake Inhibitors) at the start of the study were included. Clinical features, including information on psychiatric history and antidepressant use, were ...

by Vitor M. Almeida, Sandro R. Marana The optimum temperature is commonly determined in enzyme characterization. A search in the PubMed database for “optimum temperature” and “enzymes” yielded more than 1,700 manuscripts reporting this parameter over the last five years. Here, we show that the optimum temperature is not a constant. The catalytic activity of the mesophylic β-glucosidase Sfβgly was determined at different temperatures using different assay times and enzyme concentrations. We observed that the optimum temperature for Sfβgly changed by 5°C simply by modifying the assay length, and it was inversely correlated with enzyme concentration. These observations rely on the fact that close to the melting temperature, thermal denaturation continuously decreases the active enzyme concentration as the assay progresses. Thus, as the denaturation rate increases with increasing temperature, the bell-shaped curves observed in “activity versus temperature plots” occur only ...

by The PLOS ONE Editors

by Kevin J. Horn, R. Quinn Thomas, Christopher M. Clark, Linda H. Pardo, Mark E. Fenn, Gregory B. Lawrence, Steven S. Perakis, Erica A. H. Smithwick, Douglas Baldwin, Sabine Braun, Annika Nordin, Charles H. Perry, Jennifer N. Phelan, Paul G. Schaberg, Samuel B. St. Clair, Richard Warby, Shaun Watmough

by Grégoire Métais, Pauline M. Coster, John W. Kappelman, Alexis Licht, Faruk Ocakoğlu, Michael H. Taylor, K. Christopher Beard

by The PLOS ONE Staff