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2019年3月18日、千葉大学アカデミック・リンク・センターにおいて、2018年度第5回千葉大学アカデミック・リンク/ALPSセミナー「高等教育における著作物の利用促進とそれを支援する体制」が開催されます。 2018年度の著作権法改正にともなう授業目的公衆送信補償金制度のもとで、どのような形で、ICT を活用した授業における著作物の利用が実現するのかを広く高等教育関係者と共有することを目的に、「著作物の教育利用に関する関係者フォーラム（総合フォーラム・専門フォーラム）」の共同座長で千葉大学アカデミック・リンク・センター長／附属図書館長の竹内比呂也氏が「高等教育における著作物の利用促進とそのための環境整備」と題して報告を行います。 また、補償金制度が導入されている英国の事例について、横浜市立大学 ...

3月号ブラームスの交響曲――その本質とは3月号ピアノレッスンに コンクールをどう取り入れる？今月の１曲：ブルクミュラー《雷雨》マーラー：交響曲第3番マーラー：交響曲第6番《悲劇的》マーラー：交響曲第6番《悲劇的》タワーレコード 調べ

by Rui-Lin Yan, Yun-Feng Ye, Qin-Ying Fan, Yan-Hui Huang, Gui-Chun Wen, Li-Mei Li, Yu-Mao Cai, Tie-Jian Feng, Zhi-Ming Huang This study aimed to estimate the prevalence of chlamydial trachomatis (CT) infection and explore its risk factors among patients attending sexual and reproductive health clinics in Shenzhen, China. We collected demographic and clinical information from attendees (aged 18–49). CT and Neisseria gonorrhoeae (NG) infection was determined by nucleic acid amplification test (NAAT) on self-collected urine specimens. Of 1,938 participants recruited, 10.3% (95% confidence interval [CI]: 9.6%-11.0%) tested positive for CT. Prevalence was similar between men (10.6% [85/804]; 95% CI, 9.5%–11.7%) and women (10.1% [115/1134]; 95% CI: 9.2%–11.0%). Being 18–25 years old (adjusted odds ratio [aOR] = 2.52; 95%CI:1.35–4.71), never tested for CT before (aOR = 2.42; 95%CI: 1.05–5.61) and infected with NG(aOR = 3.87; 95%CI: 2.10–7.10) were independently associated with ...

by James Samwel Ngocho, Best Magoma, Gaudencia Alois Olomi, Michael Johnson Mahande, Sia Emmanueli Msuya, Marien Isaäk de Jonge, Blandina Theophil Mmbaga Background Despite the widespread implementation of the pneumococcal conjugate vaccine, Streptococcus pneumoniae remains the leading cause of severe pneumonia associated with mortality among children less than 5 years of age worldwide, with the highest mortality rates recorded in Africa and Asia. However, information on the effectiveness and prevalence of vaccine serotypes post-roll out remains scarce in most African countries. Hence, this systematic review aimed to describe what is known about the decline of childhood invasive pneumococcal disease post-introduction of the pneumococcal conjugate vaccine in Africa. Methods This systematic review included articles published between 2009 and 2018 on the implementation of the pneumococcal conjugate vaccine in Africa. We searched PubMed, Scopus and African Index Medicus for articles in E ...

by Huong Le Nguyen, Marie-Pierre Duviau, Muriel Cocaign-Bousquet, Sébastien Nouaille, Laurence Girbal Polysome profiling is a widely used method to monitor the translation status of mRNAs. Although it is theoretically a simple technique, it is labor intensive. Repetitive polysome fractionation rapidly generates a large number of samples to be handled in the downstream processes of protein elimination, RNA extraction and quantification. Here, we propose a multiplex polysome profiling experiment in which distinct cellular extracts are pooled before loading on the sucrose gradient for fractionation. We used the multiplexing method to study translation in E . coli . Multiplexing polysome profiling experiments provided similar mRNA translation status to that obtained with the non-multiplex method with comparable distribution of mRNA copies between the polysome profiling fractions, similar ribosome occupancy and ribosome density. The multiplexing method was used for parallel characterizati ...

by Md. Imran Khan, Tai Yuan, Ruey-Hwang Chou, Chin Yu The Ca 2+ -dependent human S100A4 (Mts1) protein is part of the S100 family. Here, we studied the interactions of S100A4 with S100A1 using nuclear magnetic resonance (NMR) spectroscopy. We used the chemical shift perturbed residues from HSQC to model S100A4 and S100A1 complex with HADDOCK software. We observed that S100A1 and the RAGE V domain have an analogous binding area in S100A4. We discovered that S100A4 acts as an antagonist among the RAGE V domain and S100A1, which inhibits tumorigenesis and cell proliferation. We used a WST-1 assay to examine the bioactivity of S100A1 and S100A4. This study could possibly be beneficial for evaluating new proteins for the treatment of diseases.

by Tadanori Teruya Wang et al. proposed a method for obtaining elliptic curves with embedding degree 1 for securing critical infrastructures, and presented several elliptic curves generated by their method with torsion points of 160 bits and 189 bits orders. They also presented some experimental results and claimed that their implementation of an elliptic curve generated with their method is faster than an implementation for embedded devices presented by Bertoni et al. In this paper, we point out that the security and efficiency claims given by Wang et al. are flawed. Specifically, we show that it is possible to solve finite field discrete logarithm problems defined over their elliptic curves in practice. On the elliptic curves with torsion points of 160 bits orders generated by Wang et al., their instances of finite field discrete logarithm problems are solved in around 4 hours by using a standard desktop PC. On the torsion points of 189 bits orders, their instances are solved in aro ...

by Vincent Macaulay, Pedro Soares, Martin B. Richards When divided by a given mutation rate, the ρ (rho) statistic provides a simple estimator of the age of a clade within a phylogenetic tree by averaging the number of mutations from each sample in the clade to its root. However, a long-standing critique of the use of ρ in genetic dating has been quite often cited. Here we show that the critique is unfounded. We demonstrate by a formal mathematical argument and illustrate with a simulation study that ρ estimates are unbiased and also that ρ and maximum likelihood estimates do not differ in any systematic fashion. We also demonstrate that the claim that the associated confidence intervals commonly estimate the uncertainty inappropriately is flawed since it relies on a means of calculating standard errors that is not used by any other researchers, whereas an established expression for the standard error is largely unproblematic. We conclude that ρ dating, alongside approaches such ...

by Cecilia Arriagada, Charlotte Luchsinger, Alexis E. González, Tomás Schwenke, Gloria Arriagada, Hugo Folch, Pamela Ehrenfeld, Patricia V. Burgos, Gonzalo A. Mardones Golgi phosphoprotein 3 (GOLPH3) is a conserved protein of the Golgi apparatus that in humans has been implicated in tumorigenesis. However, the precise function of GOLPH3 in malignant transformation is still unknown. Nevertheless, clinicopathological data shows that in more than a dozen kinds of cancer, including gliomas, GOLPH3 could be found overexpressed, which correlates with poor prognosis. Experimental data shows that overexpression of GOLPH3 leads to transformation of primary cells and to tumor growth enhancement. Conversely, the knocking down of GOLPH3 in GOLPH3-overexpressing tumor cells reduces tumorigenic features, such as cell proliferation and cell migration and invasion. The cumulative evidence indicate that GOLPH3 is an oncoprotein that promotes tumorigenicity by a mechanism that impact at different lev ...

by Riswandy Wasir, Sylvi Irawati, Amr Makady, Maarten Postma, Wim Goettsch, Erik Buskens, Talitha Feenstra Objectives This study aimed to define the problems of the current use of the e-Catalogue and the national formulary (NF)—two elements of medicine pricing and reimbursement policies in Indonesia for achieving universal health coverage (UHC)—by examining the knowledge and attitudes of stakeholders. Specifically, to investigate (1) the perceived challenges involved in the further implementation of the e-Catalogue and the NF, (2) reasons of prescribing medicines not listed in the NF, and (3) possible improvements in the acceptance and use of the e-Catalogue and the NF. Methods Semi-structured interviews were conducted with stakeholders (policymakers, healthcare providers, a pharmaceutical industry representative, and experienced patients) to collect the qualitative data. The data was analysed using directed content analysis, following the guidelines of the COnsolidated criteria f ...