リンク集 RSS/ATOM 記事

by Javier Jerez-Roig, Marina Bosque-Prous, Maria Giné-Garriga, Caritat Bagur-Calafat, Dyego L. Bezerra de Souza, Ester Teixidó-Compañó, Albert Espelt The main objective of this work was to estimate the prevalence of disability in European community-dwelling older adults, as well as to investigate differences in the profile of disabled older adults between European regions (Northern, Central, Eastern and Southern). A cross-sectional study based on wave 6 (2015) of the Survey of Health, Ageing and Retirement in Europe (SHARE) was conducted. Community-dwelling participants aged 65–84 were selected (n = 33,369). Disability was defined as presenting at least one functional limitation in basic activities of daily living (BADL). Sociodemographic, health services, lifestyle and health-related variables were analyzed. Statistical analysis was carried out through the Chi-square and ANOVA tests for bivariate analysis, and Poisson regression for multivariate analysis. Overall prevalence of ...

by Christian Baumgartner, Verena Spath-Blass, Verena Niederkofler, Katharina Bergmoser, Sonja Langthaler, Alexander Lassnig, Theresa Rienmüller, Daniela Baumgartner, Aarti Asnani, Robert E. Gerszten Metabolic biomarkers may play an important role in the diagnosis, prognostication and assessment of response to pharmacological therapy in complex diseases. The process of discovering new metabolic biomarkers is a non-trivial task which involves a number of bioanalytical processing steps coupled with a computational approach for the search, prioritization and verification of new biomarker candidates. Kinetic analysis provides an additional dimension of complexity in time-series data, allowing for a more precise interpretation of biomarker dynamics in terms of molecular interaction and pathway modulation. A novel network-based computational strategy for the discovery of putative dynamic biomarker candidates is presented, enabling the identification and verification of unexpected metabolic ...

by Shotaro Masuoka, Natsuko Kusunoki, Ryo Takamatsu, Hiroshi Takahashi, Kazuaki Tsuchiya, Shinichi Kawai, Toshihiro Nanki Objective The objective of the present study was to investigate Epstein-Barr virus (EBV) infection as an environmental factor for the development of rheumatoid arthritis (RA). Methods Synovial tissues were collected during surgery from 128 RA and 98 osteoarthritis (OA) patients. DNA was extracted from synovial tissues. The EBV gene was assessed by nested PCR for the amplification of EBV nuclear antigen-1 (EBNA-1). The nucleotide sequence of the PCR product was elucidated. HLA-DRB1 genotyping was also performed. Results EBV DNA was more frequently detected in the synovial tissues of RA patients (32.8%) than OA patients (15.3%) (p

by Takaya Segawa, Tsuyoshi Sekizuka, Satowa Suzuki, Keigo Shibayama, Mari Matsui, Makoto Kuroda Carbapenemase-producing Enterobacteriaceae (CPE) are a global concern because these bacteria are resistant to almost all β-lactams. Horizontal interspecies gene transfer via plasmid conjugation has increased the global dissemination of CPE. Recently, an Enterobacteriaceae strain positive for carbapenemase gene but showing a carbapenem-susceptible phenotype was identified, suggesting that these susceptible strains may be challenging to detect solely via antimicrobial susceptibility tests without molecular analysis. Here, we isolated a bla IMP-6 carbapenemase-gene positive but imipenem- and meropenem-susceptible Escherichia coli (ISMS-E) strain A56-1S (imipenem and meropenem minimum inhibitory concentration, ≤ 0.125 mg/L), from a human urine specimen in Japan. A56-1S was carbapenemase negative by the Carba NP test, suggesting that IMP-6 production was low or undetectable. Thus, to characte ...

by Antonia Kowallick, Charlotte Viola Fischer, Hans Hoerauf Purpose To investigate the feasibility and diagnostic benefit of routinely performed preoperative macular spectral-domain (SD-) optical coherence tomography (OCT) for the detection of macular pathology in patients with normal biomicroscopic funduscopy prior to cataract surgery. Methods Prospective, single center study. A total of 162 eyes of 123 consecutive patients referred for cataract surgery with a visual acuity better than 20/100, absence of macular symptoms such as metamorphopsia, no history of previous intravitreal procedures and a normal funduscopic appearance on biomicroscopy underwent an additional SD-OCT-examination prior to cataract surgery. OCT-scans were classified in three categories: normal, degenerative vitreous changes without impact on visual outcome or pathological with potential impact on visual outcome. Results 80 eyes (49.38%) showed normal OCT-scans. 69 eyes (42.59%) were classified as degenerative vit ...

by Abera Mersha, Nega Assefa, Kedir Teji, Shitaye Shibiru, Rasha Darghawth, Agegnehu Bante Introduction Components of essential newborn care and neonatal resuscitation are proven interventions for reducing neonatal mortality rate and stillbirth rates. Various studies have been conducted, but they failed in assessing health workers that delivered essential newborn care, facets of the health care system, and different traditional beliefs. As such, the primary aim of this study is to fill the gaps of the aforementioned previous studies, assess mothers’ current practice of essential newborn care and identify factors affecting newborn care practices in Chencha District, Southern Ethiopia. Methods A mixed type, community-based cross sectional study was conducted among 630 study participants by using one-stage cluster sampling method. Three focus group discussions (FGD) with purposively selected 18 mothers were involved for qualitative study. Data entry was carried out by Epi data version ...

by Orsolya Felde, Zsuzsa Kreizinger, Kinga Mária Sulyok, Veronika Hrivnák, Krisztián Kiss, Ákos Jerzsele, Imre Biksi, Miklós Gyuranecz Mycoplasma hyopneumoniae infections are responsible for significant economic losses in the swine industry. Commercially available vaccines are not able to inhibit the colonisation of the respiratory tract by M . hyopneumoniae absolutely, therefore vaccination can be completed with antibiotic treatment to moderate clinical signs and improve performances of the animals. Antibiotic susceptibility testing of M . hyopneumoniae is time-consuming and complicated; therefore, it is not accomplished routinely. The aim of this study was to determine the in vitro susceptibility to 15 different antibiotics of M . hyopneumoniae isolates originating from Hungarian slaughterhouses and to examine single-nucleotide polymorphisms (SNPs) in genes affecting susceptibility to antimicrobials. Minimum inhibitory concentration (MIC) values of the examined antibiotics agai ...

Beijing acts after warning of ‘serious consequences’ following Huawei CFO’s arrest

Move seeks to fulfil commitment to prevent sudden breakdown in access to UK clearinghouses

Pichai defends controversial proposal in first Congress appearance