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タイトル: Effect of prevaccination blood and T-cell phenotypes on antibody responses to a COVID-19 mRNA vaccine著者: Hidaka, Yu; Jo, Norihide; Kikuchi, Osamu; Fukahori, Masaru; Sawada, Takeshi; Shimazu, Yutaka; Yamamoto, Masaki; Kometani, Kohei; Nagao, Miki; Nakajima, Takako E.; Muto, Manabu; Morita, Satoshi; Hamazaki, Yoko抄録: Despite the high effectiveness of the coronavirus disease 2019 (COVID-19) mRNA vaccines, both immunogenicity and reactogenicity show substantial interindividual variability. One key challenge is predicting high and low responders using easily measurable parameters. In this study, we performed multivariate linear regression analysis, which allows adjustment for confounding, to explore independent predictive factors for antibody responses. Using data from 216 healthy vaccinated donors aged 23–81 years, we evaluated baseline characteristics, prevaccination blood and T-cell phenotypes, and post-vaccination T-cell responses as variables, with anti-receptor ...

タイトル: Anosov properties of a symplectic map with time-reversal symmetry著者: Okubo, Ken-ichi; Umeno, Ken抄録: This study presents a specific symplectic map, derived from a Hamiltonian, as a model that exhibits time-reversal symmetry on a microscopic scale. Based on the analysis, any initial density function, defined almost everywhere, converges to a uniform distribution in terms of mixing (irreversible behavior) on a macroscopic level. Furthermore, we established that this mixing invariant measure is a unique equilibrium state, unique Sinai–Ruelle–Bowen measure, and physical measure. Additionally, through analytical proof, we have shown that the Kolmogorov–Sinai entropy representing the average information gain per unit time is positive. This was achieved by validating Pesin's formula and demonstrating that the critical exponent of the Lyapunov exponent is 1/2.記述: 可逆なシステムにおいて時間の矢を持つのは何故か --ある時間反転対称性 ...

タイトル: Effect of Surface Functional Groups and Calcium Ion Adsorption on Formation of Polystyrene/Apatite Core-Shell Microspheres by Aqueous Solution Method著者: Yabutsuka, Takeshi; Nakanishi, Kota; Takai, Shigeomi抄録: If a method for developing organic polymer/apatite core-shell microspheres encapsulating organic polymer microspheres with apatite shells can be constructed, it is possible to establish a fundamental methodology to fabricate apatite capsules for drug delivery carriers. In this study, polystyrene (PS) microspheres were used as model substances in organic polymer microspheres, and the effects of the surface functional groups on the PS microspheres on the amount of Ca²⁺ ions introduced onto the PS microspheres were investigated. The PS/apatite core-shell microspheres were prepared by immersing Ca²⁺₋incorporated PS microspheres in a reaction solution containing Ca²⁺, HPO₄²⁻, and Mg²⁺ to coat the surface of PS microspheres with apatite. Particle ...

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