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大阪市が「（仮称）こども本の森 中之島」施設基本方針（素案）を公開するとともに、2018年6月29日から7月27日にかけてパブリックコメントを受け付けています。 同施設は大阪出身の建築家である安藤忠雄氏からの、「本や芸術文化を通じて子どもたちが豊かな創造力を育む施設として活用するため、中之島公園内に『（仮称）こども本の森 中之島』を整備し、大阪市に寄附する」、「運営費用については、広く賛同者を募り大阪市への寄附を呼びかけていきたい」という提案を契機に、建築が検討されているものです。2017年12月には負担付き寄附の受納について、市議会で議決されています。 今回公開された素案（概要）によれば、中之島公園内に延床面積約800平方メートル、3階建ての施設を建築し、2万5千冊の蔵書を大きな吹き抜けを ...

2018年7月1日、NPO法人日本独立作家同盟が出版ニュースブログ「hon.jp DayWatch」のベータ運用を開始しました。 hon.jp DayWatchは電子書籍業界のニュース配信等を行っていましたが、株式会社hon.jpの廃業に伴い、2018年1月31日にサイトを閉鎖していました。その後、日本独立作家同盟との間で事業譲渡契約が締結され、今回の運用再開に至りました。 現在はアルファテスト中に執筆されていた記事がまとめて公開されています。本格運用の開始は2018年10月1日を予定しているとのことです。 【お知らせ】ニュースブログのベータ運用を開始します（hon.jp DayWatch、2018/7/1付け） https://hon.jp/news/1.0/0/11803 続きを読む

Return to public markets offers ‘opening shot’ in what could be a long-running battle

話題を読む キーワードは「潜伏キリシタン」について

ABSTRACT Background Despite great progress in prevention and control, ischemic heart disease (IHD) remains a leading cause of global morbidity and mortality. Diet plays a key role in IHD, but a comprehensive delineation of the role of dietary factors in IHD is not yet quite complete. Objective The aim of this study was to test the long-standing hypothesis that copper is protective and zinc harmful in IHD. Design We used separate-sample instrumental variable analysis with genetic instruments (Mendelian randomization). We obtained single nucleotide polymorphisms (SNPs) from a genome wide association study, strongly ( P value < 5 × 10 ?8 ) and independently associated with erythrocyte copper and zinc. We applied these genetic predictors of copper and zinc to the largest, most extensively genotyped IHD case ( n  ? 76014)-control ( n  ? 264785) study, based largely on CARDIoGRAMplusC4D 1000 Genomes and the UK Biobank SOFT CAD, to obtain SNP-specific Wald estimates for the effec ...

タイトル: MTSS1 Regulation of Actin-Nucleating Formin DAAM1 in Dendritic Filopodia Determines Final Dendritic Configuration of Purkinje Cells著者: Kawabata Galbraith, Kelly; Fujishima, Kazuto; Mizuno, Hiroaki; Lee, Sung-Jin; Uemura, Takeshi; Sakimura, Kenji; Mishina, Masayoshi; Watanabe, Naoki; Kengaku, Mineko抄録: Dendritic filopodia of developing neurons function as environmental sensors, regulating the spatial organization of dendrites and proper targeting to presynaptic partners. Dendritic filopodia morphology is determined by the balance of F-actin assembled via two major nucleating pathways, the ARP2/3 complex and formins. The inverse-BAR protein MTSS1 is highly expressed in Purkinje cells (PCs) and has been shown to upregulate ARP2/3 activity. PCs in MTSS1 conditional knockout mice showed dendrite hypoplasia due to excessive contact-induced retraction during development. This phenotype was concomitant with elongated dendritic filopodia and was phenocopied by overactivati ...

タイトル: Evidence for line width and carrier screening effects on excitonic valley relaxation in 2D semiconductors著者: Miyauchi, Yuhei; Konabe, Satoru; Wang, Feijiu; Zhang, Wenjin; Hwang, Alexander; Hasegawa, Yusuke; Zhou, Lizhong; Mouri, Shinichiro; Toh, Minglin; Eda, Goki; Matsuda, Kazunari抄録: Monolayers of transition metal dichalcogenides (TMDC) have recently emerged as excellent platforms for exploiting new physics and applications relying on electronic valley degrees of freedom in two-dimensional (2D) systems. Here, we demonstrate that Coulomb screening by 2D carriers plays a critical role in excitonic valley pseudospin relaxation processes in naturally carrier-doped WSe2 monolayers (1L-WSe2). The exciton valley relaxation times were examined using polarization- and time-resolved photoluminescence spectroscopy at temperatures ranging from 10 to 160 K. We show that the temperature-dependent exciton valley relaxation times in 1L-WSe2 under various exciton and carrier d ...

Chancellor’s high-stakes talks with interior minister rescue CDU-CSU alliance

Experts say factors that derailed process likely to hinder sale of transfer other public sector groups

by Hakob Avetisyan, Jan Holub This paper focuses on a novel methodology of subjective speech quality measurement and repeatability of its results between laboratory conditions and simulated environmental conditions. A single set of speech samples was distorted by various background noises and low bit-rate coding techniques. This study aimed to compare results of subjective speech quality tests with and without a parallel task deploying the ITU-T P.835 methodology. Afterward, tests results performed with and without a parallel task were compared using Pearson correlation, CI95, and numbers of opposite pair-wise comparisons. The tests show differences in results in the case of a parallel task.