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タイトル: Influence of surface type on outdoor gait parameters measured using an In-Shoe Motion Sensor System著者: Shimizu, Hiroki; Tanigawa, Kyoma; Bandara, Anuradhi; Kawamoto, Shinichi; Suzuki, Shota; Nagai-Tanima, Momoko; Aoyama, Tomoki抄録: The objectives of this study were to measure outdoor gait parameters using an In-Shoe Motion Sensor System (IMS) and evaluate how different types of surfaces affect various gait dynamics. Accurate outdoor gait data are crucial for effective fall risk assessment because surface irregularities and tripping hazards often result in falls during walking. An IMS was used in this study to collect spatiotemporal, spatial, and foot parameters from 27 healthy adults walking on indoor asphalt, soil, and grass surfaces. Data were recorded during a 6-minute walk test, with measurements taken every 2 min and analyzed using the Statistical Package for the Social Sciences. The results showed significant differences in foot clearance, heel height, and ga ...

タイトル: Detailed estimation of generated woody biomass ash for use as fertilizer material著者: Ike, Minori; Kawagoe, Hiroyuki; Oshita, Kazuyuki; Takaoka, Masaki抄録: The physical and chemical characteristics of woody biomass ash (WBA) are highly dependent on the ash type, fuel, and furnace type. WBA recycling requires knowledge of its amount and characteristics. In this study, the amount of WBA recoverable as fertilizer in Japan was estimated considering the ash type, furnace type, and fuel type, using data obtained in a questionnaire-based survey of 105 of the 220 biomass power plants in Japan. The results showed that the amount of ash was > 1.5 times larger than that calculated according to fuel type. The discharged ash contained moisture, sand, and impurities. The slopes of the estimation model of the actual versus calculated amount were larger for gasification power generation, followed by stoker furnaces and fluidized bed furnaces. The bottom ash ratio in WBA from all fu ...

タイトル: Development of chimeric antigen receptor T cells targeting cancer-expressing podocalyxin著者: Mishima, Yuta; Okada, Shintaro; Ishikawa, Akihiro; Wang, Bo; Waseda, Masazumi; Kaneko, K. Mika; Kato, Yukinari; Kaneko, Shin抄録: Chimeric Antigen Receptor (CAR)-T cell therapy has revolutionized the treatment of CD19-positive B-cell malignancies. However, the field is rapidly evolving to target other antigens, such as podocalyxin (PODXL), a transmembrane protein implicated in tumor progression and poor prognosis in various cancers. This study explores the potential of PODXL-targeted CAR-T cells, utilizing a cancer-specific monoclonal antibody (CasMab) technique to enhance the specificity and safety of CAR-T cell therapy. We developed CAR-T cells based on the single-chain variable fragment (scFv) derived from the cancer-specific monoclonal antibody PcMab-6, which selectively targets glycosylation modifications on PODXL-expressing cancer cells. As a control, CAR-T cells were a ...

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