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タイトル: Maternal progesterone and adipose mPRε in pregnancy regulate the embryonic nutritional state著者: Watanabe, Keita; Yamano, Mayu; Miyamoto, Junki; Ohue-Kitano, Ryuji; Masujima, Yuki; Sasahara, Daiki; Mouri, Yuki; Kono, Nozomu; Inuki, Shunsuke; Osakada, Fumitaka; Nagaoka, Kentaro; Aoki, Junken; Sugiura, Yuki; Ohno, Hiroaki; Kondoh, Eiji; Kimura, Ikuo抄録: Sex steroid hormones such as progesterone play a pivotal role in reproductive functions and maintaining pregnancy; however, the impact of progesterone on the interaction between mother and embryo is unclear. Here, we demonstrate that the relationship between maternal progesterone and membrane progesterone receptor epsilon (mPRε) in adipose tissue regulates embryonic nutritional environment and growth after birth in mice. The activation of adipose mPRε by increased progesterone during pregnancy enhances maternal insulin resistance via prostaglandin production, efficiently providing glucose to embryos. Correspondingly ...

タイトル: PIEZO1-dependent mode switch of neuronal migration in heterogeneous microenvironments in the developing brain著者: Nakazawa, Naotaka; Grenci, Gianluca; Kameo, Yoshitaka; Takeda, Noriko; Sawada, Tsuyoshi; Kurisu, Junko; Zhang, Zhejing; Toma, Kenichi; Adachi, Taiji; Nonomura, Keiko; Kengaku, Mineko抄録: The migration of newborn neurons is essential for brain morphogenesis and circuit formation, yet controversy exists regarding how neurons generate the driving force against strong mechanical stresses in crowded neural tissues. We found that cerebellar granule neurons employ a mechanosensing mechanism to switch the driving forces to maneuver in irregular brain tissue. In two-dimensional (2D) cultures, actomyosin is enriched in the leading process, exerting traction force on the cell soma. In tissue or 3D confinement, however, actomyosin concentrates at the posterior cell membrane, generating contractile forces that assist passage through narrow spaces, working alongside t ...

Law enforcement agencies silent on what legal experts say could be a violation of the US espionage act

Nuuk makes clear it did not extend an invitation to American officials travelling there later in the week

体によくて短時間でできる魚料理はぜひ覚えたいもの。まずは、「さばのみそ煮」に挑戦してみましょう。

脂ののった新鮮なざばで、ぜひつくってみてください。さばずしにも応用できますよ。

竜田揚げは冷めてもおいしいので、お弁当にもってこいです。

シンプルに塩をふってサンマを焼く。その加減は「習うより慣れろ」です。

どんなときでもしみじみおいしいと思えるおかず。秋に食べたい野菜の煮物です。

秋野菜をおいしく、蒸した里芋でもう一品。しみじみおいしいおかず。