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Ex-president given Friday afternoon deadline to start jail sentence over corruption

適切なものを提供できず。回答プロセス:出典は新釈漢文大系の92巻「史記12 列伝5」の466ページで確認。2018/4/6 追記参考資料欄のメンテナンスを行い、ウェブページ等の内容を再度確認した。結果、以下の内容を削除した。・馬と競馬の博物館 → 現在は、公益財団法人 馬事文化財団「馬の博物館」（http://www.bajibunka.jrao.ne.jp/uma/index.html 2018/03/08確認）となっている。参考になる情報は得られなかったため、削除した。・中国古車博物館 → 事例作成時には関連があると思い掲載したが、今回改めて検索したところ中国の施設であり、旅行案内、見学記などのサイトで紹介されている記事は見ることができるだけで、公式サイトは見つからない。参考になる情報が得られないため削除した。・兵馬俑博物館 → 同じく事例作成時には関連があると ...

NGOs challenge Mark Zuckerberg’s account of how it dealt with messaging on platform

Heavily indebted conglomerate bought stake in hotel operator from Blackstone

London and Moscow’s ambassadors at UN trade barbs over Skripal case

by J. P. Lawrence, Michael Mahony, Brice P. Noonan Anti-predator signaling is highly variable with numerous examples of species employing cryptic coloration to avoid detection or conspicuous coloration (often coupled with a secondary defense) to ensure detection and recollection. While the ends of this spectrum are clear in their function, how species use intermediate signals is less clear. Australian Brood Frogs ( Pseudophryne ) display conspicuous coloration on both their dorsum and venter. Coupled with the alkaloid toxins these frogs possess, this coloration may be aposematic, providing a protective warning signal to predators. We assessed predation rates of known and novel color patterns and found no difference for avian or mammalian predators. However, when Pseudophryne dorsal phenotypes were collectively compared to the high-contrast ventral phenotype of this genus, we found birds, but not mammals, attacked dorsal phenotypes significantly less frequently than the ventral phenoty ...

by Colin P. Churchward, Alan Calder, Lori A. S. Snyder Neisseria gonorrhoeae , due to its short lipooligosaccharide structure, is generally more sensitive to the antimicrobial effects of some fatty acids than most other Gram negative bacteria. This supports recent development of a fatty acid-based potential treatment for gonococcal infections, particularly ophthalmia neonatorum. The N . gonorrhoeae genome contains genes for fatty acid resistance. In this study, the potential for genomic mutations that could lead to resistance to this potential new treatment were investigated. N . gonorrhoeae strain NCCP11945 was repeatedly passaged on growth media containing a sub-lethal concentration of fatty acid myristic acid and monoglyceride monocaprin. Cultures were re-sequenced and assessed for changes in minimum inhibitory concentration. Of note, monocaprin grown cultures developed a mutation in transcription factor gene dksA , which suppresses molecular chaperone DnaK and may be involved in t ...

by Youri Yordanov, Agnes Dechartres, Philippe Ravaud Background Cochrane reviewers are strongly encouraged to evaluate the quality of evidence for the most important outcomes by using the GRADE approach and to report these results in a Summary of Findings (SoF) table. We aimed to assess whether outcomes reported in the SoF table of Cochrane reviews could be considered patient-important outcomes (PIOs) and the quality of the available evidence for these outcomes. Methods We performed a methodological review of Cochrane reviews published between March 2011 and September 2014. For a random sample of Cochrane reviews reporting a SoF table, we extracted all outcomes reported in this table and evaluated whether they could be considered PIOs (i.e., mortality, other clinical events, adverse events, function, pain, quality of life and therapeutic decisions). Then, we collected the quality of evidence for every outcome in these SoF tables. Results We included 290 reviews issued by 47 of the 53 ...

by Kris A. Christensen, Jong S. Leong, Dionne Sakhrani, Carlo A. Biagi, David R. Minkley, Ruth E. Withler, Eric B. Rondeau, Ben F. Koop, Robert H. Devlin When unifying genomic resources among studies and comparing data between species, there is often no better resource than a genome sequence. Having a reference genome for the Chinook salmon ( Oncorhynchus tshawytscha ) will enable the extensive genomic resources available for Pacific salmon, Atlantic salmon, and rainbow trout to be leveraged when asking questions related to the Chinook salmon. The Chinook salmon’s wide distribution, long cultural impact, evolutionary history, substantial hatchery production, and recent wild-population decline make it an important research species. In this study, we sequenced and assembled the genome of a Chilliwack River Hatchery female Chinook salmon (gynogenetic and homozygous at all loci). With a reference genome sequence, new questions can be asked about the nature of this species, and its role ...

by Yuki Mizuguchi, Satoshi Morimoto, Shihori Kimura, Noriyoshi Takano, Kaoru Yamashita, Yasufumi Seki, Kanako Bokuda, Midori Yatabe, Junichi Yatabe, Daisuke Watanabe, Takashi Ando, Atsuhiro Ichihara Antithyroid drugs are generally selected as the first-line treatment for Graves’ Disease (GD); however, the existence of patients showing resistance or severe side effects to these drugs is an important issue to be solved. The (pro)renin receptor [(P)RR] is a multi-functional protein that activates the tissue renin-angiotensin system and is an essential constituent of vacuolar H + -ATPase, necessary for the autophagy-lysosome pathway. (P)RR is cleaved to soluble (s)(P)RR, which reflects the status of (P)RR expression. In this retrospective study, we aimed to investigate whether serum s(P)RR concentration can be used as a biomarker to predict the outcome of antithyroid drug treatment in GD patients. Serum s(P)RR levels were measured in 54 untreated GD patients and 47 control participants. ...