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タイトル: Brain region–specific neural activation by low-dose opioid promotes social behavior著者: Ohnami, Soichiro; Naito, Megumi; Kawase, Haruki; Higuchi, Momoko; Hasebe, Shigeru; Takasu, Keiko; Kanemaru, Ryo; Azuma, Yuki; Yokoyama, Rei; Kochi, Takahiro; Imado, Eiji; Tahara, Takeru; Kotake, Yaichiro; Asano, Satoshi; Oishi, Naoya; Takuma, Kazuhiro; Hashimoto, Hitoshi; Ogawa, Koichi; Nakamura, Atsushi; Yamakawa, Hidekuni; Ago, Yukio抄録: The opioid system plays crucial roles in modulating social behaviors in both humans and animals. However, the pharmacological profiles of opioids regarding social behavior and their therapeutic potential remain unclear. Multiple pharmacological, behavioral, and immunohistological c-Fos mapping approaches were used to characterize the effects of μ-opioid receptor agonists on social behavior and investigate the mechanisms in naive mice and autism spectrum disorder–like (ASD-like) mouse models, such as prenatally valproic acid–treated mice ...

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